Not being particularly well versed in manga, I can only compare with the established junta of Akira, Ghost in the Shell, Ninja Scroll and Legend of the Overfiend, none of which I've seen recently.
Vampire Hunter D is pretty impressive on most fronts and although didn't quite provide an experience as visceral as the examples above, it's a pleasing watch. The animation is horrifically lovely, the mythology is interesting, the fights are well staged and the Mutant Barbarois are inspired, nightmarish creations. I really love the titular character as his look, moves and cold demeanour really gets the imagination going. If I had any criticisms the overwrought finale lost my interest and the dialogue is mostly insipid.
I would love to see this made into a live action movie, maybe staring Tom Hiddleston. No doubt they would make him say "talk to the hand".
I'd be ok with that.